Invitro Scientist

Designation: Invitro ADME Scientist 

Job Location: Hyderabad

Department: Discovery Biology

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose

• Support the ADME in vitro metabolism team in drug discovery and development for small molecules.
• Conduct high-quality liver microsome and CYP inhibition assays to support ADME studies.
• Operate liquid handling systems and automation platforms with proficiency.
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed practices high level of housekeeping   
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job

Key Responsibilities:

• Plan and execute in vitro metabolism assays with extensive expertise.
• Design and perform in vitro metabolism studies, including single-point inhibition, reversible CYP IC₅₀ inhibition, and TDI-IC₅₀ shift assays using human liver microsomes.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.

Educational Qualification:  

• A M Pharm. in any pharmaceutical science or M Sc. in biological science.

Technical/functional Skills:

• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable

Experience:

• A M Pharm. in pharmaceutical sciences or M SC in biological science with Foundational years of Industrial experience in DMPK/ADME research.

Behavioral Skills:

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.