Title:  Team Leader - Protein Purification

Job Title: Research Investigator/Research Scientist

Job Location: Bangalore

About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit.

Mandatory expectation for all roles as per Syngene safety guidelines:

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene’ s quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Core Purpose of the Role:  We are seeking a skilled and enthusiastic Protein biochemist/protein purification scientist at Research Investigator level to join the Protein purification group in the Protein tech - SARC Biology, a multidisciplinary team with capabilities in molecular cloning, expression, and purification of proteins, including antibodies, bispecifics and microbially expressed proteins. The ideal candidate will have broad laboratory training, deep scientific curiosity, and a positive approach to working in a team-based research environment along with a track record of creative problem-solving and enthusiasm for taking on difficult research challenges.

Leadership Capabilities: This role is a people manager role; thus people management skills are required. 

• Excellent time management and organizational skills, and attention to detail.
• Ability to work independently and as part of a team, self-motivation, adaptability.
• Must have a high moral framework (ethics code) and high sense of data integrity values.

Syngene Values:

All employees will consistently demonstrate alignment with our core values

• Excellence
• Integrity
• Professionalism

Accountabilities as a Syngene Leader:

• Champion effective Environment, Occupational Health, Safety and Sustainability (EHSS) practices for the company and oversee compliance with those practices within Biologics business. Play an active leadership role in monitoring and verifying safety performance through Gemba walks and other safety-led activities.
• Foster a corporate culture that promotes an environment, occupational health, safety, and sustainability (EHSS) mindset as well as the highest standards of quality, integrity, and compliance.
• Put people at the heart of our success by providing clear, active leadership defined by the Syngene leadership framework setting high standards of people management, career planning and talent retention as a priority.

Experience: PhD with 1 to 3 years, M. Sc 12-15 years/M. Tech with 9-12 years

Required Technical Qualification:

• Comprehensive theoretical and practical knowledge and experience in mammalian and microbial (desirable) recombinant protein purification techniques (including affinity, ion exchange, HIC, SEC, CHT and reverse phase chromatography, TFF) and methods development. Candidates having demonstrated hands-on experience in both mammalian and microbial projects will be preferred.
• Should have experience in analytical biochemistry (SEC-HPLC, SEC-MALS/DLS, SDS PAGE, Western Blot, Protein quantification etc.)
• Strong FPLC/liquid chromatography experience – ability to program, operate, and troubleshoot purification equipment and experiments at small/pilot scale using the GE AKTA platform including AKTA PURE, Pilot, Explorer.
• DoE based process development.
• Ability to learn new techniques, perform multiple tasks simultaneously, update technical data and maintain accurate records contemporaneously, follow instructions, and comply with company policies.
• Work according to established Standard Operating Procedure (SOP) and regulatory guidance.
• Should have excellent oral, presentation and written communication skills: Team player and customer-focused
• Should have good publication record

Desired Technical Qualifications: 

• Apply mass spectrometry - based approaches, including intact mass, glycan profiling, glycosylation site and disulfide bond mapping, peptide mapping to support protein analysis and characterization.
• Additional advantage is having a demonstrated experience in optimising expression and purification of recombinant proteins from microbial source.
• Knowledge and experience in packing resins in columns like XK, HiScale and BPG.
• Knowledge in moderate throughput purification techniques (e.g-Magbeads, Coupled Columns) is desirable

Education:

M.Sc/M.Tech/PhD in biotechnology, biochemistry, structural biology, biophysics, bio-analytical chemistry, or similar scientific fields.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.