Title:  Senior Research Associate

JOB DESCRIPTION

Job Title: Associate Scientist

Job Location: Bengaluru

About Syngene:  Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific  services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene’ s quality standards at all times

Core Purpose of the Role:

The ideal candidate will be a part of dedicated multi-disciplinary drug discovery and development center set up for a leading global pharmaceutical company that allows high-performing employees to make an impact and contribute to the growth of this collaboration between Syngene and this client. You will be working along with experienced professionals in contributing towards generation of primary data and curating accurate and insightful information in exciting and fast-paced areas of antibody discovery and engineering. Applicants with expertise in antibody display technologies, such as phage and yeast, are particularly encouraged to apply.

Key Responsibilities:

• Design and execute yeast and phage display experiments aimed at discovery of tool/therapeutic antibodies for pipeline support.
• Routinely perform library generation via cloning into phagemid or yeast vectors, cell sorting via flowcytometry and screening of positive clones through FACS or ELISA.
• Design primers for different cloning strategies like infusion, restriction digestion, SDM etc.

• Analyze sequences on sequence analysis applications like sequencher, Genieous Prime.
• Develop and troubleshoot assays independently, record, analyze and communicate scientific data; ensure the accuracy and reliability of data.
• Maintaining the highest expertise in each protocol for compliance, standard operating procedures and applicable guidelines and regulations.
• Presenting results with interpretation in internal meetings.

Syngene Values: Follow safety and data integrity guideline.

All employees will consistently demonstrate alignment with our core values:

•  Excellence
•  Integrity
•  Professionalism

Education: M.Sc/M.Tech in Biotechnology, Microbiology, Cell & Molecular Biology or related life sciences discipline.

Experience: M.Sc with 6-9 yrs or M.Tech/M.Pharm with 3-6 yrs of relevant experience in antibody discovery and development.

Technical/Functional Skills:

• Strong background and experience in molecular biology techniques such as primer design, vector preparation, cloning, SDM etc.
• Comprehensive hands-on experience in phage and yeast display platforms, including library generation towards discovery of lead candidates.
• Demonstrated technical proficiency in bacterial/yeast transformation, flowcytometry, cell-sorting, cell-based assays, and ELISA to assess target-analyte interactions.
• Proficient in performing SDS-PAGE, Western Blot and DNA/protein quantitation by Nanodrop.
• Expertise in FlowJo, Geneious Prime and advanced MS Excel data analysis tools.
• Ability to perform protein quantitation and affinity measurements by Octet/SPR.
• Ability to address challenging technical problems independently and creatively.
  Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature.

Behavioral Skills: Strong problem-solving and data analysis skills, excellent written and verbal communication skills, good presentation skills, and the ability to handle multiple projects simultaneously and meet aggressive project timelines. Must demonstrate integrity and take accountability for their work.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.