Title:  Senior Research Associate -In Vitro ADME

JOB DESCRIPTION

Designation: Research Associate/ Senior Research Associate: In Vitro ADME

Job Location: Bangalore

Department: Pharmaceutical Candidate Optimization- Drug Metabolism and Transporters

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose:

This is a lab-based position, working with drug metabolism and transporter team. The major purpose will be performing in vitro ADME studies for new chemical entities and assist the team to deliver on its objectives.

Key Responsibilities:

The ideal candidate should have good understanding of In-vitro ADME assays like plasma protein binding, metabolic stability, plasma and blood stability, cytochrome P450 inhibition, and blood to plasma ratio studies.  He/She should be well versed in handling of biological matrices such as plasma, blood, microsomes, hepatocytes, S9 and cytosol. The candidate must have good data analysis skills and written and oral communication skills.  This role requires the candidate to take up some general lab related responsibilities like chemical inventory, instrument monitoring, managing lab safety. Hands on experience with transporters and/or metabolite identification is a plus for this position.

Educational Qualification and Experience:

• M.Pharm/M.Sc. with minimum 0-3 years in In-vitro DMPK.

Technical/functional Skills:

Must have:

• Preparation of compound stocks, buffers, media and other materials required for In-vitro ADME experimental work. 
• Perform In-vitro ADME assays like plasma protein binding, metabolic stability, plasma and blood stability, cytochrome P450 inhibition, and blood to plasma ratio studies.
• Handling of plasma and whole blood.
• Handling of cellular and subcellular fractions such as Microsomes, Hepatocytes, S9 and Cytosol etc.
• Use of analytical equipment such as HPLC and (u)HPLC-MS/MS will be an added advantage.
• Monitoring of consumables stock levels in the laboratory and re-stocking shelves.
• Contributing to process improvement and the sharing of new ideas within the team.

Good to have:

• Trouble shooting ability, Good communication Skills-both written and Verbal
• Good interpersonal skills and the ability to work well with other people
• Good organizational and time management skills
• Reliable and Self-motivated.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.