Scientist upstream development

JOB DESCRIPTION

Job Title: Specialist scientist/ Scientist

Job Location: Bangalore

Department: Biopharmaceutical Development

About Syngene:  Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

• Biologics Upstream research and development, Upstream process Optimization and characterization, technology transfer to GMP facility.
• Author the technical document related to Upstream process development
• Actively involve in scale-up and technology transfer to GMP manufacturing.
• Author, review protocols, reports, scale up & scale down studies, tech transfer documents, deviation and executed Batch records.
• Regular documentation of experiments contemporaneously in electronic lab notebook.
• Compilation of experimental data for further evaluation.
• Authoring technical reports and communicating the key findings.
• Participating in the weekly team meetings.
• Work closely with cross functional teams and contribute to knowledge sharing, best practices and continuous improvement initiatives.
• Ensure compliance in issuance of lab notebooks and archival of records such as logbooks, lab notebooks, protocols, reports, documents in electronic management system.
• Well versed with TrackWise or similar QMS systems

Syngene Values

All employees will consistently demonstrate alignment with our core values

•  Excellence
•  Integrity
•  Professionalism

Experience

• Should have a strong background in mammalian expression platform and bioreactors operations.
• Experience in both Upstream early and late-stage development of mAbs and fusion proteins
• Good knowledge on Upstream Process optimization and Process characterization studies
• Experienced in handling instruments like Shake flask / 3L, 5L Bioreactor / AMBR250 / Automatic cell counter / Metabolite Analyzer / Osmometer / Biosafety Cabinet
• Ability to learn quickly, enthusiastic, sincere, positive attitude, hardworking
• Basic understanding of statistics, DoE and data visualization

Skills and Capabilities

• Design, plan, conduct experiments and evaluate the outcome.
• Make detailed observations, execute, analyze data, interpret and presents results.
• Execute experiments using DoE/OFAT approach for process development and optimization.
• Expertise in operating Upstream lab instruments such as Biosafety cabinets, Incubators, Centrifuges, Vertical and Horizontal Autoclave, Vi-Cell XR/Blu, Cedex Bio /Bio HT, BGA, pH meter and Osmometer.
• Skilled in operation of shake flasks, benchtop bioreactors, ambr250.
• Co-ordinate work with other functions/departments to achieve project objectives
• Experience in using electronic lab notebook, Electronic Database Management System (EDMS), TrackWise is preferable not mandatory.

Education

•  M.Tech, or M.Sc. in Life Science/Biotechnology/ Bioprocess Engineering/ Pharmaceuticals/Biopharmaceuticals/ Biopharmaceutical Technology/ Biochemistry or equivalent degree.

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.