Title: Prinicipal Investigator
JOB DESCRIPTION
Designation: Principal Investigator
Job Location: Bangalore
Department: Discovery Biology
About Syngene
Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.
Job Purpose
Looking for a highly innovative, enthusiastic, and result-oriented individual who will lead a team of scientists, interfacing with the clients for their research and business needs and managing the activities of the Assay Development Group complying with the company quality and regulatory standards. The candidate will be involved in leading projects in the CNS therapeutic area. He/she shall be involved in guiding the team for the development and qualification of different types of cell-based and biochemical assays in the neuroscience related drug discovery projects.
Key Responsibilities:
- Scientifically contributing and leading the client FTE projects, regular updates and communications to internal and external customers on the progress of the neuroscience related projects
- Manage a team of Scientists- Masters [includes goal setting, understanding developmental needs, assigning responsibilities in the laboratory activities, critically assessing their performance and providing timely feedback]
- Scientific execution of work, developing new assays, troubleshooting the assays, data analysis and presentations
- Active participation in the strategic drives- Data Integrity and Safety; Compound management & automation based on experience
- Writing and Review of electronic laboratory notebooks, rawdata and study report to ensure data integrity for himself/herself and for reporting team
- Review reports and protocol of method development, qualification, and other studies
- Responsible for detailed planning of sample analysis and execution of protocol based studies.
- Technical data presentation in departmental and functional meetings.
- Maintains compliance with all company policies and procedures.
- Ability to build a small team and manage the daily activities of the immune-oncology assay group.
- Possess the knowledge and exposure to environment, health, and safety (EHS) practices
- Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
- Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.
Educational Qualification: Ph.D or Masters Biological sciences or related field
- Subject area (therapeutic area) expertise and in-depth technical understanding of drug discovery.
- Work experience in cell-based assays involving neuronal cells, astrocytes, glial cells
- Experience in imaging required and high content imaging as added advantage
- Experience with different target classes, MoA studies with small and/or large molecules and developing miniaturized cell-based assays, biophysical and biochemical assays.
- Experience with cell-based assays in cell lines, reporter lines, primary cells pertaining to different CNS indications
- Knowledge of QC parameters for compound screening in biochemical assays for various target classes
- In depth knowledge of handling multi-mode readers, Liquid handlers and automation
- Analyze and present data using excel, powerpoint and statistical tools (Graph Pad Prism, Excel-fit)
- Interacts with other members of the department in developing innovative technologies and assay platform.
- Knowledge in regulatory guidelines related to biosafety, and statistical data analysis.
Experience:
- 6-9 years of relevant post Ph.D
Behavioral Skills:
- Ability to manage a team of professionals to deliver quality work within the time frame, train and coach junior scientists, inculcate good work ethics.
- Ability to work with co‐workers and outside agencies professionally and tactfully.
- Excellent verbal/written communication and ability to communicate effectively with high transparency is essential.
- Interpersonal skills with an emphasis on working in a team environment to accomplish impactful results.
Equal Opportunity Employer:
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.