Title:  Principal investigator

Designation: Principal Investigator

Job Location: Bangalore

Department: In vitro biology & molecular pharmacology

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose (1-2 Lines): The candidate will be expected to lead and execute in vitro screening strategy for drug discovery programs in different therapeutic areas including oncology, immunology, cardiovascular and neuroscience.

Key Responsibilities:

1. Champion drug discovery program biology, establish in vitro assays (design, develop, troubleshoot) to drive compound structure-activity relationship including screening assays (in 384- and 1536-well formats) and mechanism of action studies
2. Independent analysis and interpretation of experimental data
3. Presentation and communication of data to stakeholders, work in collaboration with the teams within and across the department
4. Following Syngene’s data quality, integrity and EHSS guidelines

Educational Qualification: PhD in life sciences/ pharmacology/ biotechnology/ biological engineering

Technical/functional Skills:

1. Hands on experience in design and development of in vitro assays (biochemical, cell-based, signaling assays, primary cell-based assays, radioligand binding assays etc)
2. Expertise in enzyme and GPCR pharmacology and assays
3. Hands-on experience in complex cellular models/ex-vivo systems, including designing and executing mechanistic/pharmacological characterization of lead candidates
4. Hands on experience in multicolor flow cytometry, high content imaging and automation is desired
5. Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature

Experience: 0-6 years of relevant work experience

Behavioral Skills: Ability to work in a multi-disciplinary environment; strong problem solving and analytical skills; good oral and written communication, presentation skills; must demonstrate integrity and take accountability of his/her own work

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.