Title:  Invitro ADME Scientist

Designation: Invitro ADME Scientist

Job Location: Bangalore/Hyderabad

Department: Discovery Biology

About Syngene

Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply. 

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit.

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Job Purpose

• Highly lab-based role, conducting metabolism, Phys-Chem, Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well plate trans well assays using different matrices with highest quality

Key Responsibilities:

• Design and execute Caco-2, LLC-PK1-MDR1, MDCK-II-MDR1, MDCK-II BCRP transporter assays in 24 well/ 96 well/384 well plate trans well assays
• Able to handle Metabolism and Phys-Chem studies
• Reporting of executed studies without mistakes
• Raw data compilation, Report preparation, eLN updation on time.
• Presenting the study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace-ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.

Educational Qualification:  

• M Pharm. in any pharmaceutical science or M Sc. in biological science.

Technical/functional Skills:

• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• Experience in conducting cell-based assays using wild type and transporter transfected cell lines
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Report preparation and review of the reports ready to share with the clients
• Understanding the functionality, operation and maintenance of the instruments (TEER inst, Microscope, biosafety cabinet, LN2, etc.)

Experience:

• M Pharm. in pharmaceutical sciences or M SC in biological science with 1 to 10 years of Industrial experience in DMPK/ADME research.

Behavioral Skills:

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Equal Opportunity Employer:

• It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.