Title: In Vivo PK Scientist
Designation: Invivo PK Scientist
Job Location: Bangalore
Department: Discovery Biology
About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.
At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit
Mandatory expectation for all roles as per Syngene safety guidelines
Overall adherence to safe practices and procedures of oneself and the teams aligned
Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
Compliance to Syngene’ s quality standards at all times.
Job Purpose
Conduct of in vivo pharmacokinetics study in rodents
Key Responsibilities:
Conduct of pharmacokinetic studies in rodents.
Preparation of study protocols, reports for IND/ NDA submissions.
Documenting the lab notebooks online and compound management.
Ability to adapt to the dynamic team environment.
Possess the knowledge and exposure to environment, health, and safety (EHS) practices
Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team
Educational Qualification: M.Pharm / M.V.Sc (Pharmacology & Toxicology)
Technical/functional Skills:
Well versed with surgical procedures like cannulation of jugular, femoral, portal vein in rats. Chronic bile duct cannulations in rat and various animal models used for in vivo pharmacokinetics studies.
Collection of different vital organs during tissue distribution studies in rodents
Pharmacokinetic data analysis using Phoenix WinNonlin and other data analysis tool.
Collection of various biological fluids like cerebrospinal fluid, bile, urine, synovial fluid lavage during PK and tissue distribution studies in rodents.
Sound understanding about ADME assays and their correlations with pharmacokinetic parameters
Should have preliminary understanding about formulations to be used for pharmacokinetics, efficacy and toxicity studies.
Knowledge about regulatory guidelines followed for drug metabolism and pharmacokinetics is desirable.
Experience:
6-9 years post qualification
Behavioral Skills:
Candidate need to be a team player.
Ready to take new challenges, committed to work and timelines
Should have learning attitude, enthusiastic and hard working
Good in communication skills
Equal Opportunity Employer:
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.