INVITRO ADME SCIENTIST

Job Title: Invitro ADME Scientist

Job Location: Bangalore

Department: Discovery Biology

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose

• Support the ADME team by planning and conducting the metabolic stability, Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assays using Human liver microsomes with highest quality
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping   
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job

Key Responsibilities:

• Extensive experience in planning metabolic stability, CYP inhibition assays
• Design and execute in-vitro Single point inhibition, reversible CYPIC50 inhibition and TDI-IC50 shift assay with human liver microsomes.
• Seamless coordination with BA-DMPK group to design in-vitro CYP inhibition studies.
• Preparation of SOP’s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety.
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team.

Educational Qualification:  

• A M Pharm. in any pharmaceutical science or M Sc. in biological science.

Technical/functional Skills:

• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays
• In depth understanding of biochemical and aspects of enzyme kinetics is highly desirable related to the metabolism
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable

Experience:

• A M Pharm. in pharmaceutical sciences or M SC in biological science with three to six years of Industrial experience in DMPK/ADME research.

Behavioral Skills:

• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.