Title:  DSP Scientist

Job Role: Protein purification Scientist

Job Location: Bangalore

Department: Discovery Biology

About Syngene:  Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times.

Core Purpose of the Role:

• To perform protein expression and purification from various expression systems

Role Accountabilities:

• Execution of protein expression and purification projects
• Inventory management for the assigned projects
• Protein expression in bacterial & mammalian cells, and purification involving small & large scale batches (up to 20 L batch).
• Upstream and downstream process involving bacterial and mammalian systems
• Mammalian cell culture maintenance, transfection, expression optimization
• Cell culture harvest, filtration, and protein purification
• Purification of different types of tagged and non-tagged proteins, expertise in Affinity chromatography, ion-exchange chromatography, hydrophobic interaction chromatography, size-exclusion chromatography, analysis by SDS-PAGE & Western blots
• Protein refolding from Inclusion bodies and analysis of refolded protein
• The candidate should be able to purify protein in a multi-step purification within in speculated time limit
• The candidate should maintain experimental data in ELN contemporaneously
• Ability to work in a team is important and the candidate should demonstrate this objective

Syngene Values:

All employees will consistently demonstrate alignment with our core values

• Excellence
• Integrity
• Professionalism

Education: MSc or M. Pharma or M. Tech

Experience: 2-4 years

Technical / Functional Skills:

• Experience in protein expression and purification
• Well versed with all the instruments required for upstream and downstream process
• Should be conversant with bacterial and mammalian systems for Gene to protein projects
• Execution of upstream and downstream process involving bacterial and mammalian systems
• Should be conversant with SDS-PAGE, western blots, chromatographic modes of purification using AKTA purification systems 

Behavioral / Managerial skills:

• Demonstrated capabilities in leading a team and working in a matrix environment. Ability to rationally discuss data make data-driven decisions, and influence decisions to select optimal molecules for development. Ability to work in collaboration with a large inter-disciplinary team and assimilate data from various aspects. Excellent communication and presentation skills
• Experience managing multiple complex projects simultaneously requiring frequent communication, organizing/time management, and problem-solving skills
• Excellent interpersonal, communication, collaboration, analytical, and scientific project management skills
• Ability to work with senior management with professionalism and discretion

Equal Employment Opportunity:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.