Title: DMPK Scientist
Job Title: DMPK Scientist (ADME/Invitro BA)
Location: Bangalore/Hyderabad based on need
About Syngene: Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.
At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit
Mandatory expectation for all roles as per Syngene safety guidelines:
• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene’ s quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time
Core Purpose of the Role:
• To participate in sample processing for PK, ADME assays and handling of LCMS/MS. Ability to adapt to the dynamic team environment
• Processing of different matrices samples of PK studies
• Optimization of test compounds manually as well as automated on LCMS/MS
• Develop methods with the team lead
• Independently handling of HPLC for UV based samples analysis.
• Documenting the lab note books online and compound management
Syngene Values
All employees will consistently demonstrate alignment with our core values
• Excellence
• Integrity
• Professionalism
Experience:
• Minimum 2-7 years of experience in handling ADME assays and HPLC and LCMS/MS
Skills and Capabilities:
• Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory
• Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods
• Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis
• Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required
• Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra
• Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff
• General understanding of Drug metabolism and Pharmacokinetics
• Should be able to deliver scientific presentation in departmental journal club and write official Project reports
Education:
• M. Pharm in Pharmaceutical sciences, Pharmaceutical Analysis who has interest and passion for LC/MS related bioanalysis
Behavioural Skills:
• Good communication, technical report writing skills and E- Mail etiquette.
• Basic knowledge on Excel sheet and windows operations.
• Ability to meet tight deadlines and prioritize workloads.
• Should be able to work in team and flexible for working in shifts.
Equal Opportunity Employer:
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.