Associate Scientist – Preparative Chromatography

Job Title: Analytical Scientist – Preparative Chromatography

Department: Drug Substance Development and Manufacturing (Analytical Development)

Location: Bengaluru, India

Job Summary:

We are seeking a highly motivated and detail-oriented scientist to join our Preparative Chromatography team. The successful candidate will be responsible for the purification of small molecules, Drug Linkers, and other synthetic compounds using preparative HPLC, SFC and other chromatographic techniques to support drug development programs.

Key Responsibilities:

• Perform purification of crude reaction mixtures using preparative HPLC, SFC, flash chromatography, and other chromatographic methods.
• Develop and optimize purification methods for complex mixtures.
• Operate and maintain preparative chromatography instruments (e.g., Agilent, Waters, Biotage/ Grace).
• Collaborate with synthetic chemists and analytical scientists to understand purification needs and deliver high-purity compounds.
• Document purification procedures, results, and maintain accurate records in electronic lab notebooks (ELNs).
• Ensure compliance with safety and quality standards in the laboratory.
• Troubleshoot instrumentation and purification challenges independently.

Qualifications:

• M.Sc. in Organic Chemistry, Analytical Chemistry, or related field.
• 3–10 years of hands-on experience in preparative chromatography in a pharmaceutical or CRO setting.
• Strong understanding of chromatographic principles and purification strategies.
• Experience with reversed-phase and normal-phase chromatography.
• Familiarity with analytical techniques such as LC-MS, NMR, and UV detection.
• Good communication and documentation skills.

Preferred Skills:

• Experience in purification of chiral compounds or potent compounds.
• Knowledge of automation and software tools for chromatography.
• Ability to work in a fast-paced, team-oriented environment.

 Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status about public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.